Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443576 | 0.91 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8441700 | 0.89 | PKM (0.56) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8442585 | 0.89 | HTR1A (0.59) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8444817 | 0.87 | HTR1A (0.64) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8445596 | 0.86 | HTR1A (0.73) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8442659 | 0.85 | ALDH1A1 (0.55) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8446122 | 0.83 | DRD2 (0.56) | ADRA1AHTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8442064 | 0.83 | ALDH1A1 (0.56) | ADRA1AHTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7793671 | 0.81 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7029018 | 0.81 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395312-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1999-05-12 | — | — | EP | claimed |
| EP-0395313-B1 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PROD (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0955296-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-10 | — | — | EP | disclosed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | disclosed |