Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 3/20 | 1.00 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.61 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30103233 | 1.00 | PDE7A (1.00) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL31419817 | 0.87 | PDE7A (0.77) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL6283505 | 0.87 | PDE7A (0.77) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL18239987 | 0.87 | PDE7A (0.77) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL14096394 | 0.87 | PDE7A (0.77) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL3342878 | 0.85 | ALDH1A1 (1.00) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL16896092 | 0.84 | PDE7A (0.72) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL6306891 | 0.84 | PDE7A (0.71) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL6283951 | 0.84 | PDE7A (0.71) | PDE7APDE7BHTTALDH1A1RXFP1 | |
| SCHEMBL6282946 | 0.84 | ALDH1A1 (0.71) | PDE7APDE7BHTTALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170231931-A1 | PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-08-17 | — | — | US | claimed |
| EP-3185903-A1 | PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES | Fundación para la Investigación Médica Aplicada (ES) | 2017-07-05 | — | — | EP | claimed |
| WO-2016030345-A1 | PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2016-03-03 | — | — | WO | claimed |
| US-9192610-B2 | Use of quinazoline derivatives for neurodegenerative diseases | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2015-11-24 | — | — | US | claimed |
| EP-2433637-B9 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | CONSEJO SUPERIOR INVESTIGACION (ES) | 2015-06-10 | — | — | EP | claimed |
| EP-2433637-B1 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | CONSEJO SUPERIOR INVESTIGACION (ES) | 2014-06-11 | — | — | EP | claimed |
| US-20120129877-A1 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2012-05-24 | — | — | US | claimed |
| EP-2433637-A1 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2012-03-28 | — | — | EP | claimed |
| US-20260060970-A1 | Use of a Therapeutic Agent with Phosphodiesterase-7 Inhibitory Activity for the Treatment and Prevention of Diseases Associated with Chronic Fatigue, Exhaustion and/or Exertional Intolerance | MITODICURE GMBH (DE) | 2026-03-05 | — | — | US | disclosed |
| US-20230117674-A1 | MICROFLUIDIC REACTOR FOR CONTROLLING CHEMICAL REACTION AND CHEMICAL REACTION CONTROL METHOD USING THE SAME | POSTECH Research and Business Development Foundation (KR) | 2023-04-20 | — | — | US | disclosed |
| US-20210387967-A1 | 2-HETEROARYL AMINOQUINAZOLINONE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-12-16 | — | — | US | disclosed |
| US-9796687-B2 | S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2017-10-24 | — | — | US | disclosed |
| US-9796687-B2 | S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2017-10-24 | — | — | US | disclosed |
| US-20170231931-A1 | PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-08-17 | — | — | US | disclosed |
| EP-2433637-A1 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2012-03-28 | — | — | EP | disclosed |
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-4824469-A | PHENYL-, (1,2,4-TRIAZOL-1-YL- OR IMIDAZOL-1-YL-) QUINAZOLIN-4-(ONE OR THIONE) | SCHERING AGROCHEMICALS LTD. (GB) | 1989-04-25 | — | — | US | disclosed |
| US-4731106-A | Fungicidal azole compounds | SCHERING AGROCHEMICALS LIMITED (GB) | 1988-03-15 | — | — | US | disclosed |
| EP-0183458-A1 | Fungicidal azole compounds | SCHERING AGROCHEMICALS LIMITED (GB) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231931-A1 | PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES | SNCA, PSEN2, PSEN1 | PDE7A 2054/4885PDE7B 519/4885HTT 7/4885 |
| US-20210387967-A1 | 2-HETEROARYL AMINOQUINAZOLINONE DERIVATIVE | CRKL, CLIC4, CLIC1 | PDE7A 3371/4885PDE7B 3915/4885HTT 3057/4885 |
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | RNASE1, SARS1, EIF2AK2 | PDE7A 3074/4885PDE7B 2971/4885HTT 3396/4885 |
| US-20260060970-A1 | Use of a Therapeutic Agent with Phosphodiesterase-7 Inhibitory Activity for the Treatment and Prevention of Diseases Associated with Chronic Fatigue, Exhaustion and/or Exertional Intolerance | PDE5A, PDE4C, PDE12 | PDE7A 5/4885PDE7B 14/4885HTT 2169/4885 |
| US-20120129877-A1 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES | PARK7, SNCA, NLN | PDE7A 867/4885PDE7B 409/4885HTT 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.