SCHEMBL8445908

SCHEMBL8445908

COC(C)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
TSHR P16473 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22624054 0.86 ALDH1A1 (0.35) ALDH1A1
SCHEMBL19361069 0.86 ALDH1A1 (0.35) ALDH1A1
SCHEMBL11911322 0.79 ALDH1A1 (0.35) ALDH1A1
SCHEMBL11032985 0.78 LMNA (0.35) ALDH1A1
SCHEMBL14561703 0.72
SCHEMBL2297967 0.72
SCHEMBL23667242 0.72 ALDH1A1 (0.30) ALDH1A1
SCHEMBL369996 0.70
SCHEMBL1760668 0.70
SCHEMBL8568302 0.69 ALDH1A1 (0.40) ALDH1A1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-11-02 US disclosed
US-11779911-B2 Production of fatty olefin derivatives via olefin metathesis PROVIVI, INC. (US) 2023-10-10 US disclosed
EP-3551723-B1 ADDITIVES FOR LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 2023-09-20 EP disclosed
EP-3377465-B1 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS PROVIVI INC (US) 2023-08-02 EP disclosed
WO-2023001670-A1 LIQUID ELECTROLYTE COMPOSITION, AND ELECTROCHEMICAL CELL COMPRISING SAID ELECTROLYTE COMPOSITION BAYERISCHE MOTOREN WERKE AKTIENGESELLSCHAFT (DE) 2023-01-26 WO disclosed
WO-2023001671-A1 LIQUID ELECTROLYTE COMPOSITION, AND ELECTROCHEMICAL CELL COMPRISING SAID ELECTROLYTE COMPOSITION BAYERISCHE MOTOREN WERKE AKTIENGESELLSCHAFT (DE) 2023-01-26 WO disclosed
US-11542350-B2 Binuclear olefin polymerization activators DOW GLOBAL TECHNOLOGIES LLC (US) 2023-01-03 US disclosed
EP-3794663-B9 RECHARGEABLE BATTERY CELL INNOLITH TECH AG (CH) 2022-04-20 EP disclosed
US-20220032280-A1 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS PROVIVI, INC. (US) 2022-02-03 US disclosed
US-11077433-B2 Production of fatty olefin derivatives via olefin metathesis PROVIVI, INC. (US) 2021-08-03 US disclosed
EP-1737809-B1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AMGEN INC (US) 2013-09-18 EP disclosed
US-20130095428-A1 RADIATION-SENSITIVE RESIN COMPOSITION JSR CORPORATION (JP) 2013-04-18 US disclosed
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2013-04-04 US disclosed
US-8232416-B2 Method of manufacturing perfluorinated polyfunctional vinyl ether compound FUJIFILM CORPORATION (JP) 2012-07-31 US disclosed
US-8232416-B2 Method of manufacturing perfluorinated polyfunctional vinyl ether compound FUJIFILM CORPORATION (JP) 2012-07-31 US disclosed
WO-2012050641-A2 USE OF TRPA1 ANTAGONISTS TO PREVENT OR TREAT INFECTIONS CAUSED BY BIOLOGICAL-WARFARE AGENTS HYDRA BIOSCIENCES, INC (US) 2012-04-19 WO disclosed
US-20090216030-A1 METHOD OF MANUFACTURING PERFLUORINATED POLYFUNCTIONAL VINYL ETHER COMPOUND FUJIFILM CORPORATION (JP) 2009-08-27 US disclosed
EP-0513397-B1 BENZOHYDROXIMOYLAZOLE DERIVATIVE, PRODUCTION THEREOF AND INSECTICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-04-14 EP disclosed
US-5366988-A Insecticides or aphidicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-11-22 US disclosed
EP-0513397-A1 BENZOHYDROXIMOYLAZOLE DERIVATIVE, PRODUCTION THEREOF AND INSECTICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1992-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090216030-A1 METHOD OF MANUFACTURING PERFLUORINATED POLYFUNCTIONAL VINYL ETHER COMPOUND AFF1, AFF4, AFF2 ALDH1A1 1923/4885TSHR 2340/4885TDP1 2823/4885
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF CYP2C19, CYP3A7, CYP3A5 ALDH1A1 1200/4885TSHR 2282/4885TDP1 3878/4885
US-11542350-B2 Binuclear olefin polymerization activators PUF60, C9, C1S ALDH1A1 1759/4885TSHR 4834/4885TDP1 2535/4885
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF SLC5A1, SLC5A2, SLC34A1 ALDH1A1 676/4885TSHR 2374/4885TDP1 4324/4885
US-11779911-B2 Production of fatty olefin derivatives via olefin metathesis SREBF1, F2, SREBF2 ALDH1A1 1913/4885TSHR 1977/4885TDP1 4344/4885
US-11077433-B2 Production of fatty olefin derivatives via olefin metathesis SREBF1, F2, SREBF2 ALDH1A1 1913/4885TSHR 1977/4885TDP1 4344/4885
US-20220032280-A1 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS SREBF1, F2, SREBF2 ALDH1A1 1913/4885TSHR 1977/4885TDP1 4344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.