Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443619 | 0.84 | L3MBTL1 (0.49) | NPC1RAB9AMAPTALDH1A1POLB | |
| SCHEMBL23343879 | 0.83 | P2RX7 (0.50) | HPGDRAB9AMAPTALDH1A1GAA | |
| SCHEMBL11314901 | 0.82 | NPC1 (0.45) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL29657118 | 0.80 | HPGD (0.42) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8446830 | 0.80 | NPC1 (0.48) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL16906730 | 0.80 | LMNA (0.49) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8351698 | 0.79 | ACACB (0.49) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL9971091 | 0.77 | NPC1 (0.46) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL27291104 | 0.76 | TDP1 (0.45) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL15308114 | 0.76 | NPC1 (0.44) | HPGDNPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618907-B1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | BRITISH TECH GROUP INT (GB) | 1999-04-28 | — | — | EP | disclosed |