Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355983 | 0.90 | NISCH (0.37) | NISCHDDB1CRBNALDH1A1MAPT | |
| SCHEMBL1254387 | 0.78 | HTR2A (0.33) | ALDH1A1KDM4E | |
| SCHEMBL4681860 | 0.78 | GSK3B (0.33) | GSK3B | |
| SCHEMBL844231 | 0.76 | NISCH (0.39) | NISCH | |
| SCHEMBL571789 | 0.74 | SLC18A3 (0.41) | NISCHALDH1A1MAPTKDM4EHIF1A | |
| SCHEMBL1171264 | 0.73 | ALDH1A1 (0.41) | NISCHDDB1CRBNALDH1A1MAPT | |
| SCHEMBL2583636 | 0.72 | CYP3A4 (0.42) | NISCHALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3549040 | 0.72 | SLC6A2 (0.35) | — | |
| SCHEMBL3549147 | 0.72 | SLC6A2 (0.35) | NISCHRAB9ACYP1A2HIF1A | |
| SCHEMBL449107 | 0.71 | ALDH1A1 (0.44) | DDB1CRBNALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 334 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761406-B | Hydropyrido [1,2-a ] pyrazine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2024-04-19 | — | — | CN | claimed |
| EP-4069693-B1 | HYDROPYRIDO[1,2-ALPHA]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-20 | — | — | EP | claimed |
| US-20230022297-A1 | HYDROPYRIDO[1,2-a]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2023-01-26 | — | — | US | claimed |
| CN-114761406-A | Hydropyrido [1,2-a ] pyrazine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2022-07-15 | — | — | CN | claimed |
| WO-2021110614-A1 | HYDROPYRIDO[1,2-α]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-10 | — | — | WO | claimed |
| EP-2858983-B1 | TNF-ALPHA MODULATING BENZIMIDAZOLES | UCB BIOPHARMA SPRL (BE) | 2018-04-18 | — | — | EP | claimed |
| US-20170088518-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | THE BANK OF NOVA SCOTIA (CA) | 2017-03-30 | — | — | US | claimed |
| EP-2448922-B1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC (CA) | 2014-08-20 | — | — | EP | claimed |
| EP-2509946-B1 | SPIRO INDOLE-CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-04-16 | — | — | EP | claimed |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-25 | — | — | US | claimed |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-01-25 | — | — | US | claimed |
| WO-2006072792-A2 | COMPOUNDS WHICH BIND TO THE ACTIVE SITE OF PROTEIN KINASE ENZYMES | GALAPAGOS NV (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1095042-B9 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2006-07-05 | — | — | EP | claimed |
| EP-1655302-A2 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | claimed |
| EP-1095042-B1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | claimed |
| WO-2005111017-A1 | TRIAZINE COMPOUNDS AS INHIBITORS OF BACTERIAL TYPE III PROTEIN SECRETION SYSTEMS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-11-24 | — | — | WO | claimed |
| US-20050250945-A1 | Triazine compounds as inhibitors of bacterial type III protein secretion systems | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-11-10 | — | — | US | claimed |
| EP-1095042-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer Aktiengesellschaft (DE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | claimed |
| EP-0354303-A1 | Amidines of diphenyl sulfones, their derivatives and their use | AMERICAN CYANAMID COMPANY (US) | 1990-02-14 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022297-A1 | HYDROPYRIDO[1,2-a]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | TLR7, TLR9, TLR5 | NISCH 1881/4885DDB1 2105/4885CRBN 4863/4885 |
| US-20050250945-A1 | Triazine compounds as inhibitors of bacterial type III protein secretion systems | PSMB5, GTF3C3, GTF3C5 | NISCH 224/4885DDB1 1434/4885CRBN 2494/4885 |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | NISCH 1708/4885DDB1 3670/4885CRBN 4688/4885 |
| US-20170088518-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | FH, FECH, FPGS | NISCH 1375/4885DDB1 1996/4885CRBN 3488/4885 |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | GPR119, CPT1A, IRS1 | NISCH 1727/4885DDB1 2868/4885CRBN 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.