Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.45 |
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.44 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | TPH1 | P17752 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445928 | 0.87 | PKM (0.45) | SLC9A1TPH1 | |
| Hydrochloric Acid SCHEMBL8445406 | 0.85 | PKM (0.44) | HTR2BHTR7SLC9A1TPH1 | |
| Hydrochloric Acid SCHEMBL8639248 | 0.81 | HTR5A (0.46) | HTR2BHTR7 | |
| Hydrochloric Acid SCHEMBL8640890 | 0.78 | SLC9A1 (0.60) | HTR2BHTR7SLC9A1SLC9A2DRD2 | |
| Hydrochloric Acid SCHEMBL8638005 | 0.78 | CYP1A2 (0.44) | HTR2BHTR7SLC9A1 | |
| SCHEMBL7295677 | 0.78 | PKM (0.57) | — | |
| SCHEMBL14265179 | 0.76 | TPH1 (0.56) | HTR2BHTR7SLC9A1SLC9A2TPH1 | |
| Hydrochloric Acid SCHEMBL8643459 | 0.76 | POLB (0.46) | HTR2BHTR7SLC9A1SLC9A2TPH1 | |
| SCHEMBL13813415 | 0.75 | PRSS1 (0.52) | HTR2BHTR7SLC9A1SLC9A2DRD2 | |
| Hydrochloric Acid SCHEMBL8645998 | 0.75 | HTR2B (0.41) | HTR2BHTR7SLC9A1SLC9A2TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628543-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AG (DE) | 1999-06-16 | — | — | EP | claimed |
| JP-6345715-A | — | — | None | — | — | JP | disclosed |
| JP-8225514-A | — | — | None | — | — | JP | disclosed |
| EP-0628543-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AG (DE) | 1999-06-16 | — | — | EP | disclosed |
| US-5849775-A | Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5679712-A | ANTIARRHYTHMIA AGENTS, TREATMENT OF CARDIOVASCULAR, NERVOUS SYSTEM DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |
| JP-H08225514-A | SUBSTITUTED BENZOYLGUANIDINE, ITS PRODUCTION, ITS USE AS MEDICINE OR DIAGNOSTIC AGENT AND MEDICINE CONTAINING THE SAME | HOECHST AG | 1996-09-03 | — | — | JP | disclosed |
| EP-0713864-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament of diagnostic agent as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-29 | — | — | EP | disclosed |
| JP-H06345715-A | SUBSTITUTED BENZOYLGUANIDINES, THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL OR DIAGNOSTIC AND PHARMACEUTICAL CONTAINING THE SAME | HOECHST AG | 1994-12-20 | — | — | JP | disclosed |
| EP-0628543-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-14 | — | — | EP | disclosed |