Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.50 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP7 | P09237 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446264 | 1.00 | ADAMTS4 (0.52) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL8445796 | 0.89 | MMP1 (0.49) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL8446063 | 0.81 | HSD17B10 (0.44) | ADAMTS4MMP2MMP9MMP13MMP1 | |
| SCHEMBL8446061 | 0.81 | HSD17B10 (0.44) | ADAMTS4MMP2MMP9MMP13MMP1 | |
| SCHEMBL8448539 | 0.79 | ADAMTS4 (0.60) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL8448545 | 0.79 | ADAMTS4 (0.60) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL13074225 | 0.77 | MMP2 (0.68) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL698908 | 0.72 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL698907 | 0.72 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL4975578 | 0.72 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915086-A1 | PHENYLSULFONAMIDE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0915086-A1 | PHENYLSULFONAMIDE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-05-12 | — | — | EP | disclosed |