Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8059595 | 0.99 | GAA (0.38) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8073882 | 0.85 | GAA (0.39) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8073855 | 0.85 | GAA (0.35) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8446360 | 0.83 | TSHR (0.45) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8070337 | 0.83 | MAPT (0.38) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8068543 | 0.83 | TSHR (0.45) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8446986 | 0.81 | CTSZ (0.40) | GAASMN1; SMN2ALDH1A1KDM4ESCN9A | |
| Hydrochloric Acid SCHEMBL8073711 | 0.81 | ADRA1A (0.39) | KLK1F10 | |
| Hydrochloric Acid SCHEMBL8073857 | 0.81 | F10 (0.32) | SMN1; SMN2ALDH1A1KDM4ESCN9ATHRA | |
| SCHEMBL8068683 | 0.81 | SMN1; SMN2 (0.41) | HTTSMN1; SMN2KDM4EMRGPRX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | claimed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |