Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446987 | 0.85 | GAA (0.39) | GAAHTTSMN1; SMN2ALDH1A1THRA | |
| Hydrochloric Acid SCHEMBL8059595 | 0.85 | GAA (0.38) | GAAHTTSMN1; SMN2ALDH1A1THRA | |
| SCHEMBL8070326 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1THRBKDM4EMAPT | |
| SCHEMBL8059524 | 0.81 | KDM4E (0.50) | GAAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8068695 | 0.79 | ADRA1A (0.42) | THRATHRBTTRPKMPOLB | |
| SCHEMBL8073894 | 0.78 | CTSZ (0.45) | GAAHTTALDH1A1THRATHRB | |
| SCHEMBL8073502 | 0.78 | TTR (0.51) | GAAALDH1A1TTRPKMMAPT | |
| SCHEMBL8059458 | 0.77 | GPBAR1 (0.50) | — | |
| SCHEMBL7995261 | 0.74 | TTR (0.61) | ALDH1A1TTRPKMPOLBNPSR1 | |
| SCHEMBL8059681 | 0.73 | TTR (0.45) | GAASMN1; SMN2TTRPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |