SCHEMBL8447010

SCHEMBL8447010

COc1ccc(Cn2nc(O)c3cc(OC)ccc32)c(OC)c1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
APLNR P35414 1/20 0.47
KDM4E B2RXH2 3/20 0.43
MAPK1 P28482 2/20 0.43
MAPT P10636 3/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
PKM P14618 1/20 0.41
ALDH1A1 P00352 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
EGLN1 Q9GZT9 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
KDM4C Q9H3R0 1/20 0.40
GAA P10253 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8628466 0.84 CHRM1 (0.46) KDM4ETP53PKMTDP1
SCHEMBL8449970 0.83 CYP1A2 (0.49) MAPK1MAPTTP53RAB9ANPC1
SCHEMBL8448659 0.82 CNR1 (0.52) MAPK1MAPTPKMALDH1A1MEN1
SCHEMBL8625669 0.82 TUBB1 (0.44) MAPTTP53MEN1KMT2A
SCHEMBL8446733 0.81 PLA2G2A (0.48) MAPTTP53
SCHEMBL8448874 0.79 MAPT (0.49) MAPK1MAPTPKMALDH1A1MEN1
SCHEMBL8627206 0.79 BUB1 (0.44) KDM4EMAPTALDH1A1KMT2A
SCHEMBL8448901 0.78 ACHE (0.43) MAPTRAB9ANPC1PKMMEN1
SCHEMBL8441605 0.78 PTGS2 (0.50) MAPK1MAPTKMT2A
SCHEMBL6966885 0.78 KDM4E (0.50) KDM4EMAPTTP53MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP claimed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US claimed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO claimed
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP disclosed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US disclosed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO disclosed