Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444240 | 0.86 | MRGPRX1 (0.37) | MMP9ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8070680 | 0.85 | MRGPRX1 (0.36) | MMP9ALDH1A1LMNA | |
| SCHEMBL8059678 | 0.81 | NPSR1 (0.44) | NPSR1ADAMTS4MMP13ALDH1A1LMNA | |
| SCHEMBL8068849 | 0.80 | ALDH1A1 (0.54) | ALDH1A1LMNAGFERSMN1; SMN2POLB | |
| SCHEMBL8070558 | 0.78 | CYP24A1 (0.39) | NPSR1ALDH1A1GFERTDP1 | |
| SCHEMBL8073502 | 0.78 | TTR (0.51) | NPSR1ALDH1A1POLBPKM | |
| SCHEMBL8446010 | 0.77 | MAPT (0.42) | NPSR1MMP9ADAMTS4MMP13ALDH1A1 | |
| SCHEMBL8447163 | 0.76 | NPSR1 (0.41) | NPSR1MMP9ADAMTS4MMP13ALDH1A1 | |
| SCHEMBL8059681 | 0.76 | TTR (0.45) | NPSR1GFERSMN1; SMN2POLBPKM | |
| SCHEMBL8059364 | 0.76 | PKM (0.55) | ALDH1A1POLBPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |