Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845351 | 0.96 | ITGB1 (0.41) | ITGB1ITGA4HRH3PAX8TBXAS1 | |
| SCHEMBL845334 | 0.92 | ITGB1 (0.39) | ITGB1ITGA4HRH3PAX8TBXAS1 | |
| SCHEMBL872288 | 0.91 | ITGB1 (0.37) | ITGB1ITGA4HRH3PAX8TBXAS1 | |
| SCHEMBL845099 | 0.88 | ITGB1 (0.44) | ITGB1ITGA4POLBALDH1A1HTT | |
| SCHEMBL845098 | 0.84 | ITGB1 (0.43) | ITGB1ITGA4POLBALDH1A1HTT | |
| SCHEMBL10119337 | 0.82 | ADRB1 (0.36) | ITGB1ITGA4HRH3PAX8CHRNA7 | |
| SCHEMBL845190 | 0.81 | EPHX2 (0.42) | ITGB1ITGA4HTR1ADRD2PARP1 | |
| SCHEMBL873383 | 0.80 | CHRNA7 (0.36) | CHRNA7ALDH1A1HTTTHRBNAMPT | |
| SCHEMBL872553 | 0.79 | ITGB1 (0.39) | ITGB1ITGA4POLBALDH1A1HTT | |
| SCHEMBL13272435 | 0.79 | NAPRT (0.47) | ALDH1A1NAPRTTNKSPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |