Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RHOC | P08134 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845871 | 0.95 | KMT2A (0.48) | KMT2AMEN1RHOCRHOATHRB | |
| SCHEMBL874042 | 0.91 | KMT2A (0.43) | KMT2AMEN1RHOCRHOATHRB | |
| SCHEMBL845257 | 0.87 | TRPV1 (0.48) | KMT2AMEN1RHOCRHOANPSR1 | |
| SCHEMBL845008 | 0.79 | ALDH1A1 (0.54) | KMT2AMEN1NPSR1TSHRMAPT | |
| SCHEMBL874056 | 0.79 | TRPV1 (0.42) | KMT2AMEN1RHOCRHOANPSR1 | |
| SCHEMBL873200 | 0.78 | RHOC (0.48) | KMT2AMEN1RHOCRHOAMAPT | |
| SCHEMBL844996 | 0.78 | CYP2C9 (0.50) | KMT2AMEN1TRPV1HTTALDH1A1 | |
| SCHEMBL845443 | 0.78 | CYP2C9 (0.47) | RHOCRHOAMAPTTRPV1HTT | |
| SCHEMBL845284 | 0.78 | MAPK1 (0.58) | KMT2AMEN1NPSR1HTTTP53 | |
| SCHEMBL845300 | 0.78 | CYP2C9 (0.54) | RHOCRHOAMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |