Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845257 | 0.91 | TRPV1 (0.48) | TRPV1ALDH1A1TSHRCYP2C19CYP2C9 | |
| SCHEMBL874042 | 0.89 | KMT2A (0.43) | TRPV1TSHRMEN1KMT2ARHOC | |
| SCHEMBL10119502 | 0.88 | CYP2C9 (0.39) | TRPV1ALDH1A1CYP2C19CYP2C9RHOC | |
| SCHEMBL872532 | 0.88 | TRPV1 (0.44) | TRPV1ALDH1A1CYP2C19CYP2C9MAPK1 | |
| SCHEMBL10119344 | 0.88 | CYP2C9 (0.39) | TRPV1ALDH1A1CYP2C19CYP2C9RHOC | |
| SCHEMBL10119315 | 0.88 | MAPT (0.40) | TRPV1ALDH1A1CYP2C19CYP2C9MEN1 | |
| SCHEMBL874324 | 0.88 | MAPK1 (0.42) | TRPV1ALDH1A1CYP2C19CYP2C9MAPK1 | |
| SCHEMBL874313 | 0.87 | MAPK1 (0.50) | ALDH1A1TSHRCYP2C19CYP2C9MEN1 | |
| SCHEMBL873862 | 0.86 | ALDH1A1 (0.45) | TRPV1ALDH1A1TSHRCYP2C19CYP2C9 | |
| SCHEMBL871691 | 0.85 | ALDH1A1 (0.44) | TRPV1ALDH1A1TSHRCYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |