Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871771 | 0.92 | PABPC1 (0.44) | PABPC1KDM4EGAALMNARXFP1 | |
| SCHEMBL13272508 | 0.89 | GAA (0.42) | PABPC1KDM4EGAALMNARXFP1 | |
| SCHEMBL845312 | 0.86 | GAA (0.60) | PABPC1KDM4EGAALMNAHCRTR2 | |
| SCHEMBL844980 | 0.85 | ALDH1A1 (0.45) | PABPC1GAAALDH1A1KMT2APOLB | |
| SCHEMBL845708 | 0.84 | RHOC (0.46) | PABPC1LMNATSHRALDH1A1CYP2C9 | |
| SCHEMBL845710 | 0.83 | KMT2A (0.43) | PABPC1KDM4EGAALMNARXFP1 | |
| SCHEMBL845007 | 0.81 | PABPC1 (0.49) | PABPC1KDM4EGAALMNAALDH1A1 | |
| SCHEMBL845131 | 0.81 | PABPC1 (0.49) | PABPC1KDM4EGAALMNAALDH1A1 | |
| SCHEMBL845935 | 0.81 | PABPC1 (0.44) | PABPC1KDM4EGAALMNAALDH1A1 | |
| SCHEMBL845285 | 0.81 | GAA (0.48) | PABPC1KDM4EGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |