Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845181 | 0.89 | MAPT (0.69) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845438 | 0.81 | RHOC (0.41) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845729 | 0.79 | MAPT (0.58) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845568 | 0.74 | RHOC (0.36) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845592 | 0.74 | KMT2A (0.64) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845300 | 0.73 | CYP2C9 (0.54) | MAPTALDH1A1HTTPABPC1 | |
| SCHEMBL845229 | 0.73 | RHOC (0.48) | MAPTLMNAALDH1A1HTT | |
| SCHEMBL873200 | 0.72 | RHOC (0.48) | MAPTALDH1A1HTTPABPC1 | |
| SCHEMBL845541 | 0.72 | RHOC (0.49) | MAPTNPSR1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL845565 | 0.71 | KMT2A (0.35) | MAPTPOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |