Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845259 | 0.93 | KMT2A (0.30) | KMT2AALDH1A1POLB | |
| SCHEMBL845438 | 0.92 | RHOC (0.41) | RHOCRHOAMAPTNPC1KMT2A | |
| SCHEMBL845565 | 0.84 | KMT2A (0.35) | MAPTKMT2AALDH1A1POLB | |
| SCHEMBL845541 | 0.81 | RHOC (0.49) | RHOCRHOAMAPTNPC1KMT2A | |
| SCHEMBL845335 | 0.74 | MAPT (0.57) | MAPTHTTALDH1A1POLBNPSR1 | |
| SCHEMBL845229 | 0.70 | RHOC (0.48) | RHOCRHOAMAPTNPC1KMT2A | |
| SCHEMBL871839 | 0.69 | PSMB8 (0.39) | — | |
| SCHEMBL845300 | 0.68 | CYP2C9 (0.54) | RHOCRHOAMAPTHTTALDH1A1 | |
| SCHEMBL873200 | 0.67 | RHOC (0.48) | RHOCRHOAMAPTNPC1KMT2A | |
| SCHEMBL845599 | 0.67 | RHOC (0.43) | RHOCRHOANPC1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |