Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845181 | 0.89 | MAPT (0.69) | MAPTPOLBAPOBEC3AAPOBEC3GNPSR1 | |
| SCHEMBL845335 | 0.79 | MAPT (0.57) | MAPTPOLBAPOBEC3AAPOBEC3GNPSR1 | |
| SCHEMBL873200 | 0.79 | RHOC (0.48) | MAPTALDH1A1HTT | |
| SCHEMBL845008 | 0.75 | ALDH1A1 (0.54) | MAPTPOLBNPSR1LMNAALDH1A1 | |
| SCHEMBL845592 | 0.75 | KMT2A (0.64) | MAPTPOLBAPOBEC3AAPOBEC3GNPSR1 | |
| SCHEMBL844996 | 0.74 | CYP2C9 (0.50) | LMNAALDH1A1HTT | |
| SCHEMBL845257 | 0.74 | TRPV1 (0.48) | MAPTNPSR1ALDH1A1HTTTDP1 | |
| SCHEMBL845300 | 0.74 | CYP2C9 (0.54) | MAPTALDH1A1HTT | |
| SCHEMBL845007 | 0.73 | PABPC1 (0.49) | LMNAALDH1A1HTT | |
| SCHEMBL845350 | 0.73 | MAPK1 (0.49) | LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |