Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845181 | 0.81 | MAPT (0.69) | MAPTTSHRAPOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL845008 | 0.81 | ALDH1A1 (0.54) | KMT2AMAPTTSHRALDH1A1MAPK1 | |
| SCHEMBL845422 | 0.81 | KMT2A (0.46) | KMT2AMAPTTSHRALDH1A1MAPK1 | |
| SCHEMBL845598 | 0.81 | RAB9A (0.46) | KMT2AMAPTTSHRALDH1A1MAPK1 | |
| SCHEMBL845258 | 0.79 | MAPK1 (0.60) | KMT2ATSHRALDH1A1MAPK1HTT | |
| SCHEMBL845295 | 0.79 | KDM4E (0.61) | KMT2ATSHRALDH1A1MAPK1HTT | |
| SCHEMBL845089 | 0.79 | TSHR (0.45) | KMT2AMAPTTSHRALDH1A1MAPK1 | |
| SCHEMBL845774 | 0.78 | CYP2C19 (0.49) | KMT2ATSHRALDH1A1MAPK1HTT | |
| SCHEMBL873200 | 0.78 | RHOC (0.48) | KMT2AMAPTALDH1A1MAPK1HTT | |
| SCHEMBL845541 | 0.78 | RHOC (0.49) | KMT2AMAPTAPOBEC3AAPOBEC3GALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |