Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845640 | 0.88 | ALDH1A1 (0.49) | HCRTR1HCRTR2GAAKMT2AMAPT | |
| SCHEMBL845114 | 0.86 | EP300 (0.46) | LMNAALDH1A1HTTCFDDGAT1 | |
| SCHEMBL13272509 | 0.86 | TRPV1 (0.45) | PABPC1LMNAKDM4EHCRTR1HCRTR2 | |
| SCHEMBL845841 | 0.86 | TRPV1 (0.45) | PABPC1LMNAKDM4EHCRTR1HCRTR2 | |
| SCHEMBL10119342 | 0.83 | ALDH1A1 (0.45) | LMNAHCRTR1GAAKMT2AMAPT | |
| SCHEMBL845704 | 0.82 | TRPV1 (0.48) | PABPC1HCRTR1HCRTR2ALDH1A1MAPK1 | |
| SCHEMBL845699 | 0.81 | RHOC (0.48) | HCRTR1HTTDGAT1 | |
| SCHEMBL10119347 | 0.81 | ALDH1A1 (0.43) | HCRTR1HCRTR2GAAKMT2ATSHR | |
| SCHEMBL10119343 | 0.80 | ALDH1A1 (0.44) | PABPC1HCRTR2KMT2AMAPTALDH1A1 | |
| SCHEMBL10119346 | 0.80 | RHOC (0.45) | HCRTR1HCRTR2KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |