Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | EP300 | Q09472 | 3/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 2/20 | 0.41 |
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845640 | 0.95 | ALDH1A1 (0.49) | ALDH1A1TSHRNPSR1GAAHCRTR1 | |
| SCHEMBL845114 | 0.95 | EP300 (0.46) | ALDH1A1EP300CREBBPDGAT1LMNA | |
| SCHEMBL10119326 | 0.88 | EP300 (0.41) | ALDH1A1EP300CREBBPDGAT1LMNA | |
| SCHEMBL10119347 | 0.88 | ALDH1A1 (0.43) | ALDH1A1TSHRNPSR1GAAHCRTR1 | |
| SCHEMBL10119346 | 0.87 | RHOC (0.45) | ALDH1A1EP300CREBBPTSHRDGAT1 | |
| SCHEMBL845699 | 0.86 | RHOC (0.48) | EP300CREBBPDGAT1RHOARHOC | |
| SCHEMBL13272509 | 0.85 | TRPV1 (0.45) | ALDH1A1DGAT1LMNAHCRTR1 | |
| SCHEMBL845841 | 0.85 | TRPV1 (0.45) | ALDH1A1DGAT1LMNAHCRTR1 | |
| SCHEMBL845374 | 0.83 | PABPC1 (0.51) | ALDH1A1TSHRNPSR1DGAT1GAA | |
| SCHEMBL10119343 | 0.82 | ALDH1A1 (0.44) | ALDH1A1NPSR1DGAT1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |