Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912610 | 0.87 | F2 (0.42) | ITGB3ITGA2BPKMF2TMPRSS6 | |
| SCHEMBL8458587 | 0.84 | SLC1A3 (0.47) | ITGB3ITGA2BPKMSLC1A3SLC1A2 | |
| Hydrochloric Acid SCHEMBL7488066 | 0.84 | ITGB3 (0.59) | ITGB3ITGA2BMAPTITGAV | |
| SCHEMBL7398124 | 0.82 | POLB (0.45) | ITGB3ITGA2BPKMSLC1A3SLC1A2 | |
| SCHEMBL7398408 | 0.81 | ITGB3 (0.50) | ITGB3ITGA2BMEN1MAPTKMT2A | |
| SCHEMBL7402092 | 0.79 | ITGB3 (0.46) | ITGB3ITGA2BPKMMEN1LMNA | |
| Trifluoroacetic Acid SCHEMBL8459490 | 0.78 | ITGB3 (0.55) | ITGB3ITGA2BITGAV | |
| SCHEMBL8454591 | 0.76 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL7483042 | 0.76 | ITGB3 (0.63) | ITGB3ITGA2BPKMF2SLC1A3 | |
| Hydrochloric Acid SCHEMBL7494945 | 0.76 | ITGB3 (0.44) | ITGB3ITGA2BSLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |