Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | GLA | P06280 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3499274 | 1.00 | ALDH1A1 (0.77) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL13949272 | 0.90 | ALDH1A1 (0.63) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL30978209 | 0.89 | ALDH1A1 (0.63) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL7285516 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL14991107 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL411110 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL411173 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL441970 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL29763164 | 0.87 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL2282787 | 0.86 | KDM4E (0.58) | ALDH1A1POLBKDM4EHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142734-A1 | METHODS FOR TREATING TUMORS WITH THALIDOMIDE | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2012-06-07 | — | — | US | disclosed |
| US-8143283-B1 | Methods for treating blood-born tumors with thalidomide | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-7723361-B2 | Methods for inhibiting undesired angiogenesis in patients having tumors with thalidomide | CELGENE CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |
| US-7435745-B2 | Methods and compositions for inhibition of angiogenesis | CELGENE CORPORATION (US) | 2008-10-14 | — | — | US | disclosed |
| US-20080167272-A1 | Thalidomide metabolites and methods of use | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-07-10 | — | — | US | disclosed |
| US-20080167272-A1 | Thalidomide metabolites and methods of use | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-07-10 | — | — | US | disclosed |
| US-20080167272-A1 | Thalidomide metabolites and methods of use | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167272-A1 | Thalidomide metabolites and methods of use | TPMT, MALT1, FAP | ALDH1A1 202/4885POLB 1480/4885KDM4E 1460/4885 |
| US-20120142734-A1 | METHODS FOR TREATING TUMORS WITH THALIDOMIDE | PGF, FLT4, HIF1AN | ALDH1A1 231/4885POLB 2714/4885KDM4E 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.