Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845325 | 0.93 | KMT2A (0.43) | RAB9AGFERKMT2AALDH1A1MAPK1 | |
| SCHEMBL845422 | 0.84 | KMT2A (0.46) | KMT2AALDH1A1MAPK1HTTCYP2C9 | |
| SCHEMBL845592 | 0.81 | KMT2A (0.64) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL845403 | 0.78 | GFER (0.46) | GFERALDH1A1CYP2C9CYP2C19NPC1 | |
| SCHEMBL845258 | 0.78 | MAPK1 (0.60) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL844980 | 0.78 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL845421 | 0.78 | ALDH1A1 (0.42) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL845008 | 0.78 | ALDH1A1 (0.54) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL845295 | 0.77 | KDM4E (0.61) | KMT2AALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL845338 | 0.77 | RHOC (0.48) | KMT2AALDH1A1CYP2C9CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |