Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | ACR | P10323 | 2/20 | 0.44 |
| ▸ | RARA | P10276 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8839247 | 0.81 | RARA (0.44) | PRSS1ACRRARARARBRARG | |
| SCHEMBL8460896 | 0.80 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8459731 | 0.79 | RARA (0.48) | PRSS1ACRRARARARBRARG | |
| SCHEMBL8839216 | 0.74 | RARA (0.40) | PRSS1RARARARBRARGSNCA | |
| SCHEMBL8459684 | 0.74 | CYP3A4 (0.43) | RARARARBRARGSNCAALDH1A1 | |
| SCHEMBL8839322 | 0.73 | KDM4E (0.39) | RARARARBRARGKDM4EALDH1A1 | |
| SCHEMBL7594781 | 0.71 | LMNA (0.46) | SNCAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL6430392 | 0.71 | MAPT (0.63) | SNCAKDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL9737345 | 0.71 | HSP90AA1 (0.50) | RARARARBRARGSNCAALDH1A1 | |
| SCHEMBL21376220 | 0.70 | HSD17B2 (0.61) | RARARARBRARGKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869067-A | TREATING DERMATOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5753239-A | Bi-aromatic compounds and pharmaceutical and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DEMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1998-05-19 | — | — | US | disclosed |