Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9486281 | 0.86 | SMN1; SMN2 (0.64) | ALDH1A1MAPTMAPK1NR1H4SMN1; SMN2 | |
| SCHEMBL8839247 | 0.83 | RARA (0.44) | ALDH1A1MAPTMAPK1NR1H4SMN1; SMN2 | |
| SCHEMBL8460899 | 0.81 | PKM (0.64) | ALDH1A1MAPTNR1H4SMN1; SMN2PKM | |
| SCHEMBL8458030 | 0.80 | PRSS1 (0.44) | ALDH1A1MAPTSMN1; SMN2NPC1MEN1 | |
| SCHEMBL8442730 | 0.78 | NR1H4 (0.53) | ALDH1A1MAPTMAPK1NR1H4SMN1; SMN2 | |
| SCHEMBL22067604 | 0.78 | MEN1 (0.56) | ALDH1A1MAPTMAPK1SMN1; SMN2PKM | |
| SCHEMBL8839216 | 0.77 | RARA (0.40) | ALDH1A1MAPTNR1H4SMN1; SMN2NPC1 | |
| SCHEMBL8457513 | 0.77 | RARA (0.49) | ALDH1A1MAPTMAPK1SMN1; SMN2PKM | |
| SCHEMBL8839322 | 0.75 | KDM4E (0.39) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5604917 | 0.74 | NPC1 (0.69) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869067-A | TREATING DERMATOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5753239-A | Bi-aromatic compounds and pharmaceutical and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DEMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1998-05-19 | — | — | US | disclosed |