Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL8449647 | 0.95 | TLR8 (0.37) | TLR8P4HBTRPM8 | |
| SCHEMBL7896415 | 0.95 | TLR8 (0.40) | TLR8P4HBSMN1; SMN2TRPM8MAPT | |
| Tetrabuthylammonium SCHEMBL7896503 | 0.91 | TLR8 (0.39) | TLR8TRPM8MAPTGAACASP1 | |
| Tetrabuthylammonium SCHEMBL7902648 | 0.90 | AGTR1 (0.36) | TLR8SMN1; SMN2TRPM8MAPTMEN1 | |
| Tetrabuthylammonium SCHEMBL7904701 | 0.89 | TLR8 (0.35) | TLR8TRPM8 | |
| SCHEMBL7903985 | 0.73 | KDM4E (0.34) | SMN1; SMN2MAPTMEN1KMT2ACASP1 | |
| SCHEMBL7904676 | 0.64 | RAB9A (0.33) | SMN1; SMN2MAPTMEN1KMT2AALOX15 | |
| SCHEMBL7908493 | 0.63 | HTR1B (0.33) | ALDH1A1 | |
| SCHEMBL8885044 | 0.61 | RAB9A (0.55) | SMN1; SMN2MAPT | |
| Tetrabuthylammonium SCHEMBL28207923 | 0.60 | ALDH1A1 (0.59) | TLR8ALDH1A1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |