Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL8449647 | 0.90 | TLR8 (0.37) | TLR8TRPM8IKBKB | |
| Tetrabuthylammonium SCHEMBL8458162 | 0.89 | TLR8 (0.37) | TLR8TRPM8 | |
| Tetrabuthylammonium SCHEMBL7902648 | 0.87 | AGTR1 (0.36) | TLR8TRPM8 | |
| Tetrabuthylammonium SCHEMBL7896503 | 0.87 | TLR8 (0.39) | TLR8TRPM8IKBKB | |
| SCHEMBL7896415 | 0.84 | TLR8 (0.40) | TLR8TRPM8 | |
| SCHEMBL7908493 | 0.74 | HTR1B (0.33) | — | |
| SCHEMBL7903985 | 0.66 | KDM4E (0.34) | — | |
| SCHEMBL7903994 | 0.64 | ATP4A (0.40) | — | |
| SCHEMBL7904676 | 0.61 | RAB9A (0.33) | — | |
| SCHEMBL8885044 | 0.58 | RAB9A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |