SCHEMBL8458456

SCHEMBL8458456

CS(=O)(=O)c1ccc(CN2CCCN(CCC(=O)O)CC2)cc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 18/20 0.65
LMNA P02545 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6770077 0.87 CCR2 (0.65) CCR2LMNA
SCHEMBL6776114 0.86 CCR2 (0.58) CCR2LMNA
SCHEMBL6770035 0.82 KDM4E (0.57) CCR2
SCHEMBL8236801 0.80 HRH3 (0.64) CCR2LMNA
SCHEMBL7922568 0.80 CCR2 (0.59) CCR2LMNA
SCHEMBL22516895 0.78 CCR2 (0.59) CCR2LMNA
SCHEMBL23775497 0.77 CCR2 (0.59) CCR2LMNA
SCHEMBL22639905 0.77 SIGMAR1 (0.61)
SCHEMBL2115134 0.77 KMT2A (0.69) LMNA
SCHEMBL16256960 0.76 CCR2 (0.57) CCR2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0914319-A1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS TEIJIN LIMITED (JP) 1999-05-12 EP disclosed
WO-1997044329-A1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS TEIJIN LIMITED (JP) 1997-11-27 WO disclosed