Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852989 | 1.00 | REN (0.40) | RENAAK1CTSDCTSSCTSK | |
| SCHEMBL8458000 | 0.86 | REN (0.50) | RENCTSD | |
| SCHEMBL8460695 | 0.86 | REN (0.50) | RENCTSD | |
| SCHEMBL7633741 | 0.85 | KLK5 (0.41) | CTSSCTSK | |
| SCHEMBL7633738 | 0.85 | KLK5 (0.41) | CTSSCTSK | |
| SCHEMBL8853149 | 0.84 | REN (0.45) | REN | |
| SCHEMBL8458897 | 0.84 | REN (0.45) | REN | |
| SCHEMBL7436803 | 0.82 | REN (0.45) | RENCTSSCTSK | |
| SCHEMBL7436801 | 0.82 | REN (0.45) | RENCTSSCTSK | |
| SCHEMBL8459147 | 0.81 | AAK1 (0.39) | RENAAK1CTSDCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935976-A | Antiviral ethers of aspartate protease substrate isosteres | NOVARTIS CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
| US-5807891-A | RETROVIRUSES | NOVARTIS AG (CH) | 1998-09-15 | — | — | US | disclosed |
| US-5663200-A | CARBAMOYL PEPTIDE DERIVATIVES AS VIRICIDES | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0708085-A2 | Antiviral ethers of aspartate protease substrate isosteres | CIBA-GEIGY AG (CH) | 1996-04-24 | — | — | EP | disclosed |