Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459579 | 0.80 | PTK2 (0.50) | MAPK1L3MBTL1MAPTPTK2LIPE | |
| SCHEMBL8973202 | 0.77 | GABRA1 (0.50) | MAPK1L3MBTL1MAPTTSHRGABRA5 | |
| SCHEMBL27682589 | 0.75 | LIPE (0.43) | MAPK1L3MBTL1MAPTPTK2LIPE | |
| SCHEMBL27379515 | 0.73 | PTK2 (0.49) | L3MBTL1PTK2LIPETSHRGABRA5 | |
| SCHEMBL27934674 | 0.73 | ALDH1A1 (0.45) | MAPK1L3MBTL1MAPTPTK2LIPE | |
| SCHEMBL4634081 | 0.71 | L3MBTL1 (0.44) | L3MBTL1PTK2LIPETSHRNPSR1 | |
| SCHEMBL4634579 | 0.71 | LIPE (0.47) | L3MBTL1PTK2LIPETSHRGABRA5 | |
| SCHEMBL14169846 | 0.70 | TRPA1 (0.39) | MAPK1L3MBTL1MAPTPTK2LIPE | |
| SCHEMBL28938017 | 0.70 | ADRA2A (0.43) | L3MBTL1MAPTPTK2LIPE | |
| SCHEMBL3363976 | 0.70 | PTK2 (0.46) | L3MBTL1PTK2LIPEGABRA5CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385210-B1 | Amidation of pyridines | HOFFMANN LA ROCHE (CH) | 1995-02-15 | — | — | EP | disclosed |
| EP-0385210-A2 | Amidation of pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-05 | — | — | EP | disclosed |