SCHEMBL846136

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	Sipagladenant SCHEMBL879438	0.89	L3MBTL1 (0.47)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL1255727	0.89	RAB9A (0.57)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL10331934	0.88	L3MBTL1 (0.46)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL846371	0.87	L3MBTL1 (0.44)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL1257097	0.87	L3MBTL1 (0.46)	NPC1HPGDRAB9ASMN1; SMN2L3MBTL1
	SCHEMBL879437	0.87	L3MBTL1 (0.46)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL1256235	0.86	TRPV4 (0.49)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL845536	0.86	L3MBTL1 (0.43)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL1256278	0.85	KDM4E (0.50)	TDP1NPC1HPGDXBP1RAB9A
	SCHEMBL846999	0.85	L3MBTL1 (0.43)	TDP1NPC1HPGDXBP1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.