Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.63 |
| ▸ | RARG | P13631 | 9/20 | 0.63 |
| ▸ | RARA | P10276 | 7/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.63 |
| ▸ | BLVRB | P30043 | 1/20 | 0.63 |
| ▸ | RXRA | P19793 | 12/20 | 0.62 |
| ▸ | RXRB | P28702 | 9/20 | 0.62 |
| ▸ | RXRG | P48443 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888067 | 0.87 | RARB (0.66) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL3935577 | 0.85 | L3MBTL1 (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9282594 | 0.83 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9208986 | 0.83 | RXRA (0.78) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8458958 | 0.82 | RXRA (0.69) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8839090 | 0.80 | RARB (0.70) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7723495 | 0.80 | RARB (0.74) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9747007 | 0.80 | RARA (0.62) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL29373818 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL36207 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |