Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846954 | 0.95 | TRPV1 (0.45) | ACHETRPV1KDM4ENPC1TP53 | |
| SCHEMBL846566 | 0.89 | HSD17B10 (0.44) | ACHETRPV1KDM4ENPC1TP53 | |
| SCHEMBL847501 | 0.86 | KDM4E (0.48) | ACHEKDM4ENPC1TP53RAB9A | |
| SCHEMBL846304 | 0.85 | TRPV1 (0.57) | TRPV1KDM4ENPC1RAB9A | |
| SCHEMBL846407 | 0.82 | NPC1 (0.47) | KDM4ENPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL846485 | 0.80 | HSD17B10 (0.43) | TRPV1KDM4ENPC1TP53RAB9A | |
| SCHEMBL846194 | 0.80 | TRPV1 (0.59) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL846869 | 0.79 | NOTUM (0.50) | KDM4ENPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL859840 | 0.78 | NPC1 (0.50) | TRPV1KDM4ENPC1TP53RAB9A | |
| SCHEMBL846663 | 0.77 | TRPV1 (0.48) | TRPV1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |