Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846407 | 0.94 | NPC1 (0.47) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846419 | 0.86 | ACHE (0.47) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846869 | 0.85 | NOTUM (0.50) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846566 | 0.84 | HSD17B10 (0.44) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL859840 | 0.84 | NPC1 (0.50) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846429 | 0.83 | NPC1 (0.57) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846954 | 0.82 | TRPV1 (0.45) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846445 | 0.81 | KDM4E (0.48) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846528 | 0.81 | KDR (0.48) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL846485 | 0.81 | HSD17B10 (0.43) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |