Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846419 | 0.95 | ACHE (0.47) | TRPV1RAB9AHSD17B10ACHEKDM4E | |
| SCHEMBL846566 | 0.94 | HSD17B10 (0.44) | TRPV1RAB9AHSD17B10LMNAPOLB | |
| SCHEMBL846407 | 0.85 | NPC1 (0.47) | RAB9AHSD17B10LMNAPOLBTSHR | |
| SCHEMBL846194 | 0.85 | TRPV1 (0.59) | TRPV1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL846485 | 0.83 | HSD17B10 (0.43) | TRPV1RAB9AHSD17B10LMNAPOLB | |
| SCHEMBL846869 | 0.82 | NOTUM (0.50) | RAB9AHSD17B10TSHRKDM4ENPC1 | |
| SCHEMBL847501 | 0.82 | KDM4E (0.48) | RAB9AHSD17B10LMNAPOLBTSHR | |
| SCHEMBL846304 | 0.80 | TRPV1 (0.57) | TRPV1RAB9AKDM4ENPC1 | |
| SCHEMBL846528 | 0.79 | KDR (0.48) | RAB9AHSD17B10LMNAPOLBKDM4E | |
| SCHEMBL846669 | 0.78 | TRPV1 (0.58) | TRPV1RAB9AKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |