Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847501 | 0.94 | KDM4E (0.48) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846869 | 0.88 | NOTUM (0.50) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846566 | 0.88 | HSD17B10 (0.44) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846954 | 0.85 | TRPV1 (0.45) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846528 | 0.85 | KDR (0.48) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846485 | 0.84 | HSD17B10 (0.43) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846445 | 0.83 | KDM4E (0.48) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846303 | 0.82 | NPC1 (0.60) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL846565 | 0.82 | SMN1; SMN2 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL846419 | 0.82 | ACHE (0.47) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |