Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846869 | 0.89 | NOTUM (0.50) | MAPTTP53RAB9AKDM4ENPC1 | |
| SCHEMBL846485 | 0.85 | HSD17B10 (0.43) | LMNAMAPTTP53POLBRAB9A | |
| SCHEMBL846565 | 0.85 | SMN1; SMN2 (0.47) | LMNAMAPTTP53POLBRAB9A | |
| SCHEMBL846634 | 0.85 | KDR (0.61) | KDRLMNAMAPTRAB9AKDM4E | |
| SCHEMBL846407 | 0.85 | NPC1 (0.47) | KDRLMNAMAPTTP53POLB | |
| SCHEMBL847501 | 0.81 | KDM4E (0.48) | KDRLMNAMAPTTP53POLB | |
| SCHEMBL846566 | 0.81 | HSD17B10 (0.44) | LMNATP53POLBRAB9AKDM4E | |
| SCHEMBL846445 | 0.80 | KDM4E (0.48) | KDRLMNATP53RAB9AKDM4E | |
| SCHEMBL846954 | 0.79 | TRPV1 (0.45) | LMNATP53POLBRAB9AKDM4E | |
| SCHEMBL16494394 | 0.78 | TP53 (0.58) | LMNAMAPTTP53RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |