Acetic Acid

Acetic Acid

SCHEMBL8465174

CC(=O)[O-].Clc1ccc([S+](c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.45
CES1 P23141 2/20 0.45
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
TSHR P16473 3/20 0.40
ALOX15 P16050 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
MAPT P10636 1/20 0.39
NR4A1 P22736 1/20 0.39
FLT1 P17948 1/20 0.39
FLT4 P35916 1/20 0.39
KDR P35968 1/20 0.39
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
BRD4 O60885 1/20 0.37
CA12 O43570 1/20 0.37
CA3 P07451 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL106040 0.87 CA2 (0.44) CES2CES1CA1CA2TSHR
Benzoic Acid SCHEMBL31501033 0.87 CA2 (0.59) CES2CES1CA1CA2TSHR
SCHEMBL92023 0.85 TSHR (0.53) CES2CES1TSHRALOX15L3MBTL1
SCHEMBL1535668 0.85 TSHR (0.53) CES2CES1TSHRALOX15L3MBTL1
Benzoyl Formic Acid SCHEMBL699654 0.84 CES2 (0.56) CES2CES1CA1CA2TSHR
Bromide SCHEMBL3139794 0.83 TSHR (0.50) CES2CES1TSHRALOX15L3MBTL1
Iodide SCHEMBL6930682 0.83 TSHR (0.50) CES2CES1TSHRALOX15L3MBTL1
Bromide SCHEMBL3129122 0.83 TSHR (0.50) CES2CES1TSHRALOX15L3MBTL1
Acetic Acid SCHEMBL547513 0.82 FNTA (0.44) CES2CA1CA2MAPTGAA
Perchlorate SCHEMBL3136664 0.81 TSHR (0.43) CES2CES1TSHRL3MBTL1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6001932-A ACRYLIC ESTER COPOLYMER WITH VINYL ETHER, VINYL ESTER COPOLYMERS FOR RUBBER BLENDS NIPPON MEKTRON, LIMITED (JP) 1999-12-14 US disclosed
EP-0755952-B1 Acrylic copolymer elastomer, its blend rubber and blend rubber composition NIPPON MEKTRON KK (JP) 1999-10-20 EP disclosed
US-5744562-A GOOD HEAT RESISTANCE AND AMINE RESISTANCE WITH FLUORINE-CONTAINING ELASTOMER NIPPON MEKTRON, LIMITED (JP) 1998-04-28 US disclosed
EP-0755952-A2 Acrylic copolymer elastomer, its blend rubber and blend rubber composition NIPPON MEKTRON, LTD. (JP) 1997-01-29 EP disclosed
EP-0039365-B1 EPICHLOROHYDRIN ELASTOMER COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1986-06-04 EP disclosed
US-4358559-A CURABLE TO TACK-FREE ELASTOMERIC ARTICLES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1982-11-09 US disclosed
US-4343861-A Fluoroelastomer/polyepichlorohydrin elastomer articles MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1982-08-10 US disclosed
EP-0039365-A4 EPICHLOROHYDRIN ELASTOMER COMPOSITIONS. MINNESOTA MINING & MFG (US) 1982-03-03 EP disclosed
EP-0039365-A1 EPICHLOROHYDRIN ELASTOMER COMPOSITIONS. MINNESOTA MINING & MFG (US) 1981-11-11 EP disclosed
US-4293663-A SHAPING, CURING MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1981-10-06 US disclosed
US-4287322-A POLYPHENOL CURING AGENT MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1981-09-01 US disclosed
WO-1981001150-A1 EPICHLOROHYDRIN ELASTOMER COMPOSITIONS MINNESOTA MINING & MFG (US) 1981-04-30 WO disclosed
US-4233421-A AROMATIC POLYHYDROXY CO-CURATIVE IN A THERMALLY STABLE, CORROSION RESISTANT POLYMER MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1980-11-11 US disclosed