Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084959 | 0.83 | ALOX5 (0.47) | KDRMAPKAPK2AURKAMAP3K9MAP3K11 | |
| SCHEMBL8468841 | 0.82 | ALOX5 (0.53) | KDRMAPKAPK2AURKAMAP3K9MAP3K11 | |
| SCHEMBL8467392 | 0.73 | RXFP1 (0.52) | KDRMAPKAPK2ALOX5ROCK2RXFP1 | |
| SCHEMBL8072870 | 0.72 | ALOX5 (0.55) | KDRMAPKAPK2AURKAALOX5ROCK2 | |
| SCHEMBL8082188 | 0.68 | ALOX5 (0.49) | ALOX5ROCK2CDK4CCND1 | |
| SCHEMBL20992953 | 0.68 | MAP3K9 (0.47) | MAPKAPK2MAP3K9MAP3K11PDE3BPDE3A | |
| SCHEMBL20992951 | 0.68 | CLK4 (0.47) | KDRMAP3K9MAP3K11FLT3NTRK1 | |
| SCHEMBL8085101 | 0.68 | ALOX5 (0.52) | KDRMAPKAPK2ALOX5ROCK2 | |
| SCHEMBL8081908 | 0.67 | ALOX5 (0.49) | MAPKAPK2ALOX5GPR35ROCK2 | |
| SCHEMBL26506265 | 0.67 | ABCG2 (0.47) | KDRMAPKAPK2AURKAALOX5FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |