SCHEMBL8466658

SCHEMBL8466658

Cc1cccc2c1C(=O)c1c(nc3ccc(Cl)cn13)C2=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
GAA P10253 9/20 0.42
MAPT P10636 3/20 0.42
TP53 P04637 4/20 0.41
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PIK3CD O00329 1/20 0.40
PIK3R1 P27986 1/20 0.40
MAP3K14 Q99558 1/20 0.40
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
POLB P06746 1/20 0.39
USP8 P40818 1/20 0.39
TRPA1 O75762 1/20 0.38
AKT1 P31749 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8464922 0.95 HSP90AA1 (0.44) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8465088 0.90 GAA (0.42) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8465034 0.90 GAA (0.42) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8465227 0.83 HSP90AA1 (0.63) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8465211 0.81 S100A4 (0.46) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8465103 0.81 HSP90AA1 (0.69) HSP90AA1HSP90AB1
SCHEMBL8468193 0.77 HSP90AA1 (0.51) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8467667 0.77 TP53 (0.46) HSP90AA1HSP90AB1GAATP53ALDH1A1
SCHEMBL8465123 0.76 S100A4 (0.46) HSP90AA1HSP90AB1GAAMAPTTP53
SCHEMBL8464963 0.75 HSP90AA1 (0.69) HSP90AA1HSP90AB1USP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed