SCHEMBL8467667

SCHEMBL8467667

O=C1C(=O)c2c(nc3ccc(Cl)cn23)-c2cccc(Cl)c21

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
PARP1 P09874 1/20 0.37
TRPA1 O75762 2/20 0.37
PKM P14618 1/20 0.37
AKT1 P31749 1/20 0.37
AKT2 P31751 1/20 0.37
BACE1 P56817 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALDH1A1 P00352 1/20 0.35
HTR6 P50406 1/20 0.35
PKLR P30613 1/20 0.35
NSD2 O96028 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465034 0.87 GAA (0.42) TP53GAAHSP90AA1HSP90AB1TRPA1
SCHEMBL8468193 0.85 HSP90AA1 (0.51) TP53GAAHSP90AA1HSP90AB1PARP1
SCHEMBL8464968 0.83 S100A4 (0.43) TP53GAAHSP90AA1HSP90AB1CYP1A2
SCHEMBL8464828 0.83 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8465088 0.80 GAA (0.42) TP53GAAHSP90AA1HSP90AB1TRPA1
SCHEMBL8465227 0.79 HSP90AA1 (0.63) TP53GAAHSP90AA1HSP90AB1PARP1
SCHEMBL8464922 0.77 HSP90AA1 (0.44) TP53GAAHSP90AA1HSP90AB1TRPA1
SCHEMBL8466658 0.77 HSP90AA1 (0.44) TP53GAAHSP90AA1HSP90AB1TRPA1
SCHEMBL8139750 0.74 GAA (0.43) TP53GAAPKMCYP1A2CYP2C9
SCHEMBL8465211 0.73 S100A4 (0.46) TP53GAAHSP90AA1HSP90AB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed