SCHEMBL8464968

SCHEMBL8464968

O=C1C(=O)c2c(nc3ccc(Cl)cn23)-c2cccc([N+](=O)[O-])c21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.43
PTPRC P08575 1/20 0.40
LCK P06239 1/20 0.39
TP53 P04637 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 3/20 0.36
KMT2A Q03164 2/20 0.36
RECQL P46063 1/20 0.36
MCL1 Q07820 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
AURKA O14965 1/20 0.36
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
CA7 P43166 1/20 0.35
MAOB P27338 1/20 0.35
CA12 O43570 1/20 0.35
HTT P42858 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465211 0.91 S100A4 (0.46) S100A4PTPRCLCKTP53GAA
SCHEMBL8465123 0.91 S100A4 (0.46) S100A4PTPRCLCKTP53GAA
SCHEMBL8464823 0.83 S100A4 (0.42) S100A4PTPRCLCKMAPTKMT2A
SCHEMBL8465017 0.82 HSP90AA1 (0.56) S100A4PTPRCKMT2AHSP90AA1HSP90AB1
SCHEMBL8468193 0.79 HSP90AA1 (0.51) S100A4TP53GAAMAPTHSP90AA1
SCHEMBL8465227 0.73 HSP90AA1 (0.63) TP53GAAMAPTKMT2AHSP90AA1
SCHEMBL8466603 0.73 HSP90AA1 (0.63) S100A4PTPRCKMT2AHSP90AA1HSP90AB1
SCHEMBL8464981 0.73 HSP90AA1 (0.63) S100A4PTPRCKMT2AHSP90AA1HSP90AB1
SCHEMBL8464922 0.71 HSP90AA1 (0.44) TP53GAAMAPTHSP90AA1HSP90AB1
SCHEMBL8466658 0.71 HSP90AA1 (0.44) TP53GAAMAPTHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed