SCHEMBL8467758

SCHEMBL8467758

C=C(C)C(=O)Nc1ccc(Nc2ccc(OCC)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.64
KMT2A Q03164 2/20 0.64
CYP1A2 P05177 2/20 0.64
MEN1 O00255 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
POLB P06746 2/20 0.59
MAPT P10636 8/20 0.59
ALDH1A1 P00352 4/20 0.58
FAAH O00519 1/20 0.54
SMN1; SMN2 Q16637 5/20 0.52
RAB9A P51151 4/20 0.52
NPC1 O15118 4/20 0.51
KDM4E B2RXH2 2/20 0.51
MAPK1 P28482 2/20 0.51
HTT P42858 1/20 0.51
HPGD P15428 1/20 0.50
TP53 P04637 1/20 0.50
SCN1A P35498 1/20 0.50
SCN2A Q99250 1/20 0.50
SCN3A Q9NY46 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8476280 0.95 LMNA (0.70) LMNAKMT2ACYP1A2MEN1TDP1
SCHEMBL14926811 0.83 FAAH (0.59) LMNAFAAHSMN1; SMN2
SCHEMBL8465748 0.83 NPC1 (0.58) KMT2ACYP1A2MEN1TDP1POLB
SCHEMBL11554938 0.82 KMT2A (0.55) LMNAKMT2ACYP1A2MEN1TDP1
Phenacetin SCHEMBL10630698 0.80 KMT2A (0.96) LMNAKMT2ACYP1A2MEN1TDP1
SCHEMBL10204609 0.80 ALDH1A1 (0.56) LMNAKMT2ACYP1A2MEN1TDP1
SCHEMBL8468299 0.79 TGM2 (0.62) LMNAKMT2ACYP1A2MEN1TDP1
SCHEMBL10204605 0.79 ALDH1A1 (0.55) LMNAKMT2ACYP1A2MEN1TDP1
Phenacetin SCHEMBL23280 0.79 KMT2A (1.00) LMNAKMT2ACYP1A2MEN1TDP1
Phenacetin SCHEMBL18894356 0.79 KMT2A (1.00) LMNAKMT2ACYP1A2MEN1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US claimed
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US disclosed
EP-0570825-B1 Tire sidewall composition containing silica having low PH GOODYEAR TIRE & RUBBER (US) 1996-08-07 EP disclosed
EP-0475215-B1 Carboxylic acid esters with thio groups GOODYEAR TIRE & RUBBER (US) 1994-10-19 EP disclosed
EP-0570825-A1 Tire sidewall composition containing silica having low PH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-11-24 EP disclosed
US-5244028-A Natural rubber or polybutadiene, silica, antidegradation agent, carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-14 US disclosed
US-5216049-A A phenolic or amine stabilizer and an organothioalkylene styrene bound to a polymer; aging resistance; rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-06-01 US disclosed
EP-0475215-A1 Carboxylic acid esters with thio groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-18 EP disclosed
US-5069819-A SYNERGISTS FOR CONVENTIONAL PHENOLIC AND AMINE ANTIOXIDANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed