Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | EDNRB | P24530 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080528 | 0.91 | PTGS2 (0.41) | PTGS2PTGDR2ARHSP90AA1HSP90AB1 | |
| SCHEMBL8081363 | 0.82 | PTGS2 (0.44) | PTGS2HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL8080596 | 0.76 | PTGS2 (0.42) | PTGS2HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL8072765 | 0.75 | PTGS2 (0.45) | PTGS2HSP90AA1HSP90AB1ALDH1A1HPGD | |
| SCHEMBL8081438 | 0.74 | PTGS2 (0.36) | PTGS2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8072887 | 0.74 | PTGS2 (0.43) | PTGS2HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL8081344 | 0.74 | PTGS2 (0.42) | PTGS2KDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8081905 | 0.71 | ALOX5 (0.45) | KDM4EALDH1A1HPGDEDNRBPKM | |
| SCHEMBL8086666 | 0.68 | PTGS2 (0.44) | PTGS2HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL8072434 | 0.67 | TARBP2 (0.38) | PTGS2KDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |