Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081363 | 0.88 | PTGS2 (0.44) | PTGS2HSP90AA1HSP90AB1CASP3SENP8 | |
| SCHEMBL8085173 | 0.86 | ALDH1A1 (0.46) | ALDH1A1MAPK1EDNRBEDNRAKDM4E | |
| SCHEMBL8081344 | 0.85 | PTGS2 (0.42) | PTGS2ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8081515 | 0.85 | EDNRA (0.45) | ALDH1A1KMT2ANPC1RAB9AEDNRB | |
| SCHEMBL8080596 | 0.76 | PTGS2 (0.42) | PTGS2HSP90AA1HSP90AB1CASP3SENP8 | |
| SCHEMBL8081905 | 0.75 | ALOX5 (0.45) | ALDH1A1MAPK1EDNRBEDNRAKDM4E | |
| SCHEMBL8084890 | 0.74 | EDNRA (0.45) | ALDH1A1NPC1EDNRBEDNRAKDM4E | |
| SCHEMBL8467959 | 0.74 | PTGS2 (0.42) | PTGS2HSP90AA1HSP90AB1ALDH1A1KMT2A | |
| SCHEMBL8072411 | 0.73 | ALDH1A1 (0.42) | ALDH1A1MAPK1EDNRBEDNRAKDM4E | |
| SCHEMBL8084976 | 0.72 | EDNRB (0.50) | ALDH1A1SMN1; SMN2EDNRBEDNRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |