Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789818 | 0.77 | CRHR1 (0.38) | CRHR1SMPD3 | |
| SCHEMBL5790968 | 0.71 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL27515662 | 0.70 | CRHR1 (0.36) | CRHR1SMPD3 | |
| SCHEMBL5787555 | 0.69 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL27555107 | 0.63 | S100B (0.36) | CRHR1TP53 | |
| SCHEMBL6920917 | 0.61 | CRHR1 (0.40) | CRHR1SMPD3 | |
| SCHEMBL5789801 | 0.58 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL23854312 | 0.56 | POLB (0.55) | — | |
| SCHEMBL31673873 | 0.56 | POLB (0.55) | — | |
| SCHEMBL28930366 | 0.56 | ALDH1A3 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923582-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008847-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |