Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859840 | 0.83 | NPC1 (0.50) | NPC1RAB9AALDH1A1KDRKDM4E | |
| SCHEMBL16494235 | 0.82 | ACHE (0.52) | RAB9AALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL846301 | 0.82 | KDR (0.60) | NPC1RAB9AALDH1A1KDRKDM4E | |
| SCHEMBL4108874 | 0.78 | KDR (0.63) | NPC1RAB9AALDH1A1KDRKDM4E | |
| SCHEMBL846407 | 0.78 | NPC1 (0.47) | NPC1RAB9AALDH1A1KDRKDM4E | |
| SCHEMBL846869 | 0.76 | NOTUM (0.50) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL847501 | 0.76 | KDM4E (0.48) | NPC1RAB9AALDH1A1KDRKDM4E | |
| SCHEMBL16494430 | 0.75 | SMN1; SMN2 (0.51) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16494263 | 0.75 | MAPT (0.54) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL846528 | 0.75 | KDR (0.48) | NPC1RAB9AALDH1A1KDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |