Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985563 | 0.86 | KDM4E (0.48) | IGFBP3KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8472216 | 0.85 | KDM4E (0.42) | IGFBP3KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8470642 | 0.84 | PLK1 (0.42) | PDE4AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL10995233 | 0.83 | ADORA2A (0.52) | IGFBP3MAP2K4PTGER1NR4A1NR4A2 | |
| SCHEMBL10986803 | 0.83 | KMO (0.49) | PDE4AKDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL10986938 | 0.80 | KMO (0.52) | KDM4EMEN1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL10991830 | 0.77 | LMNA (0.49) | KDM4EMEN1ALDH1A1GLAHPGD | |
| SCHEMBL10995427 | 0.77 | DHODH (0.49) | KDM4EMEN1KMT2AHSD17B10LMNA | |
| SCHEMBL8470659 | 0.77 | TSPO (0.59) | IGFBP3KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8470699 | 0.76 | ABCG2 (0.37) | PDE4AALDH1A1CYP1A2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998624-A | MEDICAL DIAGNOSIS; BINDING TO SITE OF INJURY, INFLAMMATION | EMORY UNIVERSITY (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1998049900-A1 | HALOISOQUINOLINE CARBOXAMIDE | EMORY UNIVERSITY (US) | 1998-11-12 | — | — | WO | disclosed |