Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834051 | 0.76 | CYP1A2 (0.43) | CYP11B1CYP11B2ALDH1A1MAPTTP53 | |
| SCHEMBL8484476 | 0.74 | RPS6KA5 (0.37) | ALDH1A1MAPTTP53SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL3843975 | 0.68 | CYP11B1 (0.45) | CYP11B1CYP11B2THRBMAPTTP53 | |
| SCHEMBL8485408 | 0.65 | NFATC1 (0.36) | MAPTTP53AOC3HTT | |
| SCHEMBL13036058 | 0.64 | CYP19A1 (0.59) | CYP11B1CYP11B2ALDH1A1MAPTTP53 | |
| SCHEMBL16756519 | 0.63 | TSHR (0.52) | CYP11B1CYP11B2ALDH1A1MAPTTP53 | |
| SCHEMBL9923549 | 0.62 | NR1D1 (0.48) | CYP11B1CYP11B2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12205 | 0.62 | CYP11B1 (1.00) | CYP11B1CYP11B2MAPTPOLBCYP1A2 | |
| SCHEMBL11539964 | 0.62 | LTA4H (0.49) | CYP11B1CYP11B2ALDH1A1MAPTPOLB | |
| SCHEMBL8128782 | 0.62 | TAAR1 (0.57) | CYP11B1CYP11B2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |